I found that my anxiety comes and goes IN PART depending on what I eat. I finally pieced that together. (I want to emphasize "in part" because I don't think that is where it stems from 100%, but at least 70-80) I read parts of a book written by a pediatric immunologist called "Is this your child". Very insightful read. She postulates that many disorders in children including ADHD, agression, misbehavior, etc, is caused by unidentified food/environmental allergies. When the allergens are diagnosed in the child and then subsequently removed, these undesirable behaviors disappear. She has hard evidence to back this up. A very interesting and informative read. I can, through anecdotal evidence, say that once I ate almonds and then 15 minutes later I was feeling really angry and hyper for no reason and then I connected the almonds and my behavior. I think that many of us who have IC do have allergies caused by a permeable gut. Food proteins are leaking across the gut to the blood stream and then our immune systems go crazy b/c stuff that should not be there is there. When this happens, our bodies build antibodies to seemingly benign things like apples, etc. For me, now when I eat many foods like apples/peaches/cherries, etc, my mouth itches, throat swells, etc. Maybe one thing you might explore is having an allergy test to see what you are allergic to and then cut those things out to see if that helps with the anxiety. I would ask Matia though because if you do a skin test, they do inject allergens and this would probably make your whole body go nuts. I know that when I am "bad" and I eat sugar my heart starts racing wildly and I get crazy. Hope this helps. Good luck and keep us posted.